ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04120
Name Ubiquitin mediated proteolysis
Description  Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
No. of Genes in ADHDgene  29
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 29)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 8q13.3 1(0/0/1)
TRIM32 tripartite motif containing 32 9q33.1 1(0/0/1)
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 6q25.2-q27 1(1/0/0)

Genes from other sources Help(count: 26)

Approved Symbol Approved Name Location Source
DDB1 damage-specific DNA binding protein 1, 127kDa 11q12-q13 Mapped by significant region
BIRC6 baculoviral IAP repeat containing 6 2p22.3 Mapped by CNV
UBE4A ubiquitination factor E4A 11q23.3 Mapped by significant region
PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) 11q12.2 Mapped by significant region
MID1 midline 1 (Opitz/BBB syndrome) Xp22 Mapped by PBA pathway
UBE2L6 ubiquitin-conjugating enzyme E2L 6 11q12.1 Mapped by significant region
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 11q23.3-qter Mapped by significant region
TRIP12 thyroid hormone receptor interactor 12 2q36.3 Mapped by PBA pathway
UBA6 ubiquitin-like modifier activating enzyme 6 4q13.2 Mapped by significant region
SKP2 S-phase kinase-associated protein 2 (p45) 5p13 Mapped by significant region
UBOX5 U-box domain containing 5 20p13 Mapped by CNV
SYVN1 synovial apoptosis inhibitor 1, synoviolin 11q13 Mapped by significant region
RCHY1 ring finger and CHY zinc finger domain containing 1 4q21.1-q21.3 Mapped by CNV
CUL5 cullin 5 11q22.3 Mapped by PBA pathway; Mapped by significant region
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 5q12.1 Mapped by CNV
WWP1 WW domain containing E3 ubiquitin protein ligase 1 8q21 Mapped by CNV
HERC3 hect domain and RLD 3 4q21 Mapped by CNV
CDC26 cell division cycle 26 homolog (S. cerevisiae) 9q32 Mapped by significant region
ANAPC4 anaphase promoting complex subunit 4 4p15.31 Mapped by CNV
RFWD2 ring finger and WD repeat domain 2 1q25.1-q25.2 Mapped by significant region
BIRC2 baculoviral IAP repeat containing 2 11q22 Mapped by significant region
BIRC3 baculoviral IAP repeat containing 3 11q22 Mapped by significant region
HERC2 hect domain and RLD 2 15q13 Mapped by significant region
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 18q21 Mapped by significant region
FBXO4 F-box protein 4 5p12 Mapped by significant region
UBE3A ubiquitin protein ligase E3A 15q11.2 Mapped by CNV; Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014