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- Data Summary
GO Report
Basic Info
| ID | GO:0070374 |
|---|---|
| Name | positive regulation of ERK1 and ERK2 cascade |
| Type | Biological Process |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 22)
Literature-origin genes (count: 6)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| OPRM1 | opioid receptor, mu 1 | 6q24-q25 | 1(1/0/0) | |
| ARRB1 | arrestin, beta 1 | 11q13 | 2(1/1/0) | IDA[10644702] |
| ARRB2 | arrestin, beta 2 | 17p13 | 1(1/0/0) | IDA[10644702]; IMP[12582207] |
| ADRA1A | adrenergic, alpha-1A-, receptor | 8p21.2 | 3(2/1/0) | |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 10(3/7/0) | |
| FGF10 | fibroblast growth factor 10 | 5p13-p12 | 1(0/1/0) | IDA[14975937] |
Genes from other sources (count: 16)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| FGF19 | fibroblast growth factor 19 | Mapped by significant region | IDA[17623664] |
| IL6 | interleukin 6 (interferon, beta 2) | Mapped by significant region | |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | Mapped by significant region | |
| MAPK3 | mitogen-activated protein kinase 3 | Mapped by CNV | IMP[19664780] |
| ARHGAP8 | Rho GTPase activating protein 8 | Mapped by CNV | |
| VEGFB | vascular endothelial growth factor B | Mapped by significant region | IDA[18259607] |
| TLR4 | toll-like receptor 4 | Mapped by significant region | |
| CTGF | connective tissue growth factor | Mapped by significant region | |
| FLT4 | fms-related tyrosine kinase 4 | Mapped by CNV | IMP[11532940] |
| EDNRA | endothelin receptor type A | Mapped by PBA pathway | |
| FGF4 | fibroblast growth factor 4 | Mapped by significant region | IDA[17167778] |
| NOX4 | NADPH oxidase 4 | Mapped by significant region | |
| PYCARD | PYD and CARD domain containing | Mapped by CNV | |
| MIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Mapped by CNV | IDA[17045821] |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | Mapped by significant region | IMP[11544529] |
| CCL19 | chemokine (C-C motif) ligand 19 | Mapped by LD-proxy | IDA[15778365] |