Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
GO Report
Basic Info
| ID | GO:0007187 |
|---|---|
| Name | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| Type | Biological Process |
| No. of Genes in ADHDgene | 18 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 18)
Literature-origin genes (count: 14)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | 6q13 | 13(5/8/0) | TAS[1559993] |
| MTNR1B | melatonin receptor 1B | 11q21-q22 | 1(0/0/1) | TAS[7568007] |
| HTR1E | 5-hydroxytryptamine (serotonin) receptor 1E | 6q14-q15 | 2(2/0/0) | TAS[1733778] |
| HTR5A | 5-hydroxytryptamine (serotonin) receptor 5A | 7q36.1 | 1(0/1/0) | |
| MTNR1A | melatonin receptor 1A | 4q35 | 1(1/0/0) | TAS[9645677] |
| HTR1F | 5-hydroxytryptamine (serotonin) receptor 1F | 3p12 | 1(0/1/0) | TAS[8380639] |
| HTR7 | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | 10q21-q24 | 1(0/1/0) | TAS[8226867] |
| DRD1 | dopamine receptor D1 | 5q34-q35 | 8(5/3/0) | IDA[1282671] |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4 | 5q31-q33 | 1(1/0/0) | TAS[9603189] |
| ADRB3 | adrenergic, beta-3-, receptor | 8p12 | 2(0/2/0) | TAS[2570461] |
| OPRM1 | opioid receptor, mu 1 | 6q24-q25 | 1(1/0/0) | TAS[7905839] |
| CNR1 | cannabinoid receptor 1 (brain) | 6q14-q15 | 1(1/0/0) | TAS[1718258] |
| HTR1D | 5-hydroxytryptamine (serotonin) receptor 1D | 1p36.3-p34.3 | 2(1/1/0) | TAS[1565658] |
| HTR6 | 5-hydroxytryptamine (serotonin) receptor 6 | 1p36-p35 | 2(0/2/0) |
Genes from other sources (count: 4)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| MC2R | melanocortin 2 receptor (adrenocorticotropic hormone) | Mapped by CNV | TAS[9175632] |
| NPY | neuropeptide Y | Mapped by CNV; Mapped by significant region | TAS[8132547] |
| MC5R | melanocortin 5 receptor | Mapped by CNV | TAS[7739752] |
| MC1R | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | Mapped by significant region | TAS[9571181] |