ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007187
Name G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Type biological process
No. of Genes in ADHDgene  19
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 19)

Literature-origin genes (count: 14)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0) TAS[2570461]
MTNR1A melatonin receptor 1A 4q35 1(1/0/0) TAS[9645677]
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3p12 1(0/1/0) TAS[8380639]
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 1(0/1/0) TAS[8226867]
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0) TAS[1559993]
OPRM1 opioid receptor, mu 1 6q24-q25 1(1/0/0) TAS[7905839]
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 1(0/1/0) IEA
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 1(1/0/0) TAS[9603189]
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0) TAS[1718258]
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1p36.3-p34.3 2(1/1/0) TAS[1565658]
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 2(0/2/0) IEA
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0) IDA[1282671]
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6q14-q15 2(2/0/0) TAS[1733778]
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1) TAS[7568007]

Genes from other sources Help (count: 5)

Approved Symbol Approved Name Source Evidence[PMID]
SSTR5 somatostatin receptor 5 Mapped by significant region TAS[7908405]
MC5R melanocortin 5 receptor Mapped by CNV TAS[7739752]
NPY neuropeptide Y Mapped by CNV; Mapped by significant region TAS[8132547]
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) Mapped by CNV TAS[9175632]
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Mapped by significant region TAS[9571181]