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- Data Summary
GO Report
Basic Info
| ID | GO:0007243 |
|---|---|
| Name | intracellular protein kinase cascade |
| Type | Biological Process |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 19)
Literature-origin genes (count: 4)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| ADRA1A | adrenergic, alpha-1A-, receptor | 8p21.2 | 3(2/1/0) | TAS[10671514] |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 10(3/7/0) | IDA[1331329] |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 7q35-q36 | 1(0/0/1) | IMP[15877279] |
| ADRA1B | adrenergic, alpha-1B-, receptor | 5q33.3 | 2(1/1/0) | TAS[10820200] |
Genes from other sources (count: 15)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| SMPD2 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | Mapped by PBA pathway | |
| THOP1 | thimet oligopeptidase 1 | Mapped by LD-proxy | |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | Mapped by significant region | IDA[9792677] |
| ITGB1BP1 | integrin beta 1 binding protein 1 | Mapped by significant region | TAS[9813144] |
| PLA2G1B | phospholipase A2, group IB (pancreas) | Mapped by PBA pathway | ISS[15528384] |
| WNK2 | WNK lysine deficient protein kinase 2 | Mapped by significant region | |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | Mapped by significant region | IDA[14976552] |
| SIK2 | salt-inducible kinase 2 | Mapped by significant region | IDA[14976552] |
| SS18 | synovial sarcoma translocation, chromosome 18 | Mapped by significant region | |
| FYB | FYN binding protein | Mapped by significant region | TAS[9207119] |
| MAP4K2 | mitogen-activated protein kinase kinase kinase kinase 2 | Mapped by significant region | IDA[11784851] |
| PRKAG3 | protein kinase, AMP-activated, gamma 3 non-catalytic subunit | Mapped by significant region | TAS[10698692] |
| MC1R | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | Mapped by significant region | ISS[18292087] |
| PRKD1 | protein kinase D1 | Mapped by significant region | IMP[18440775] |
| LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | Mapped by significant region | IDA[10871863] |