ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004091
Name	carboxylesterase activity
Type	Molecular Function
No. of Genes in ADHDgene	40
Source	Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)

Data Set Reference	Gene Set	Mapping Rule	P-value	FDR	Result Link
Neale BM, 2008	MsigDB 3.0 c5.mf	5kb upstream and downstream of gene	< 0.001	0.008	Link

Comments for this pathway (count: 1)

PMID	Citation	Comment
19733552	Nemoda Z, Angyal N,et al. Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD. Neuropharmacology 2009, 57(7-8):731-733.	This result warrants for further investigations of the CES1 ...... This result warrants for further investigations of the CES1 gene in larger ADHD samples. More...

GO related genes in ADHDgene (count: 40)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
LPL	lipoprotein lipase	8p22	1(0/0/1)

Genes from other sources (count: 39)

Approved Symbol	Approved Name	Source
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	Mapped by PBA pathway
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway
LYPLA1	lysophospholipase I	Mapped by PBA pathway
LGALS13	lectin, galactoside-binding, soluble, 13	Mapped by PBA pathway
CES1	carboxylesterase 1	Mapped by PBA pathway
PLA2G4B	phospholipase A2, group IVB (cytosolic)	Mapped by PBA pathway
SIAE	sialic acid acetylesterase	Mapped by significant region
MGLL	monoglyceride lipase	Mapped by PBA pathway
PNLIPRP1	pancreatic lipase-related protein 1	Mapped by PBA pathway
AADAC	arylacetamide deacetylase (esterase)	Mapped by PBA pathway
BCHE	butyrylcholinesterase	Mapped by CNV
AOAH	acyloxyacyl hydrolase (neutrophil)	Mapped by PBA pathway
PON2	paraoxonase 2	Mapped by PBA pathway
PNLIPRP2	pancreatic lipase-related protein 2	Mapped by PBA pathway
LIPE	lipase, hormone-sensitive	Mapped by PBA pathway
CES2	carboxylesterase 2	Mapped by PBA pathway
PLA2G3	phospholipase A2, group III	Mapped by PBA pathway
CES1P1	carboxylesterase 1 pseudogene 1	Mapped by LD-proxy; Mapped by PBA pathway
PNPLA8	patatin-like phospholipase domain containing 8	Mapped by PBA pathway
NLGN1	neuroligin 1	Mapped by CNV
CES5A	carboxylesterase 5A	Mapped by LD-proxy
PLA2G10	phospholipase A2, group X	Mapped by PBA pathway; Mapped by significant region
ACHE	acetylcholinesterase	Mapped by PBA pathway
PNLIP	pancreatic lipase	Mapped by PBA pathway
ABHD3	abhydrolase domain containing 3	Mapped by significant region
PPME1	protein phosphatase methylesterase 1	Mapped by PBA pathway; Mapped by significant region
PLA1A	phospholipase A1 member A	Mapped by PBA pathway
PLA2G2E	phospholipase A2, group IIE	Mapped by PBA pathway
LIPF	lipase, gastric	Mapped by PBA pathway
PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	Mapped by PBA pathway
ABHD15	abhydrolase domain containing 15	Mapped by LD-proxy
PNPLA3	patatin-like phospholipase domain containing 3	Mapped by PBA pathway
PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)	Mapped by PBA pathway
LIPG	lipase, endothelial	Mapped by PBA pathway
PRDX6	peroxiredoxin 6	Mapped by PBA pathway; Mapped by significant region
APOC2	apolipoprotein C-II	Mapped by PBA pathway
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	Mapped by significant region
PLA2G2D	phospholipase A2, group IID	Mapped by PBA pathway