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- Data Summary
GO Report
Basic Info
| ID | GO:0008144 |
|---|---|
| Name | drug binding |
| Type | Molecular Function |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 19)
Literature-origin genes (count: 10)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| SLC18A2 | solute carrier family 18 (vesicular monoamine), member 2 | 10q25 | 2(0/2/0) | |
| DRD3 | dopamine receptor D3 | 3q13.3 | 8(1/7/0) | IDA[8413587] |
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 5p15.3 | 68(42/25/1) | |
| HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | 6q13 | 13(5/8/0) | |
| CNR1 | cannabinoid receptor 1 (brain) | 6q14-q15 | 1(1/0/0) | |
| DRD4 | dopamine receptor D4 | 11p15.5 | 67(49/18/0) | IDA[8413587] |
| ADRB1 | adrenergic, beta-1-, receptor | 10q24-q26 | 2(0/2/0) | |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A | 13q14-q21 | 12(6/6/0) | IDA[15831837] |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 10(3/7/0) | IDA[8413587] |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | Xq24 | 5(2/3/0) | IDA[15831837] |
Genes from other sources (count: 9)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | Mapped by LD-proxy | TAS[8954936] |
| UGT1A8 | UDP glucuronosyltransferase 1 family, polypeptide A8 | Mapped by LD-proxy; Mapped by literature SNP | |
| DHFRP1 | dihydrofolate reductase pseudogene 1 | Mapped by significant region | IDA[15039552] |
| PDE4D | phosphodiesterase 4D, cAMP-specific | Mapped by CNV | IPI[15938621] |
| UGT1A7 | UDP glucuronosyltransferase 1 family, polypeptide A7 | Mapped by LD-proxy; Mapped by literature SNP | |
| CHRM3 | cholinergic receptor, muscarinic 3 | Mapped by CNV; Mapped by PBA pathway | |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | Mapped by significant region | IDA[15938621]; IPI[15938621] |
| CHRM1 | cholinergic receptor, muscarinic 1 | Mapped by PBA pathway; Mapped by significant region | |
| CHKA | choline kinase alpha | Mapped by significant region | IDA[19915674] |