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- Data Summary
GO Report
Basic Info
| ID | GO:0000187 |
|---|---|
| Name | activation of MAPK activity |
| Type | Biological Process |
| No. of Genes in ADHDgene | 21 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 21)
Literature-origin genes (count: 7)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| NTF3 | neurotrophin 3 | 12p13 | 3(1/2/0) | |
| ITGA1 | integrin, alpha 1 | 5q11.1 | 1(0/1/0) | |
| FGF10 | fibroblast growth factor 10 | 5p13-p12 | 1(0/1/0) | IDA[14975937] |
| MAP2K3 | mitogen-activated protein kinase kinase 3 | 17q11.2 | 1(0/1/0) | |
| CHRNA7 | cholinergic receptor, nicotinic, alpha 7 | 15q13.3 | 2(0/1/1) | IDA[10771023] |
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) | |
| DRD4 | dopamine receptor D4 | 11p15.5 | 67(49/18/0) | IDA[15755724] |
Genes from other sources (count: 14)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| MAPK3 | mitogen-activated protein kinase 3 | Mapped by CNV | |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | Mapped by significant region | NAS[11546797] |
| MAPK1 | mitogen-activated protein kinase 1 | Mapped by LD-proxy | |
| TLR4 | toll-like receptor 4 | Mapped by significant region | |
| LPAR1 | lysophosphatidic acid receptor 1 | Mapped by significant region | |
| C5 | complement component 5 | Mapped by significant region | TAS[7649993] |
| UBC | ubiquitin C | Mapped by CNV | |
| UBB | ubiquitin B | Mapped by significant region | |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | Mapped by significant region | IMP[15258589] |
| C1QTNF2 | C1q and tumor necrosis factor related protein 2 | Mapped by significant region | |
| GNG3 | guanine nucleotide binding protein (G protein), gamma 3 | Mapped by significant region | TAS[10075696] |
| GHR | growth hormone receptor | Mapped by CNV; Mapped by significant region | |
| PLCE1 | phospholipase C, epsilon 1 | Mapped by PBA pathway | IDA[11022047] |
| PLA2G1B | phospholipase A2, group IB (pancreas) | Mapped by PBA pathway | ISS[15528384] |