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KEGG Pathway Report
Basic Info
| ID | hsa04540 |
|---|---|
| Name | Gap junction |
| Description | Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. |
| No. of Genes in ADHDgene | 27 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 27)
Literature-origin genes (count: 8)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ADRB1 | adrenergic, beta-1-, receptor | 10q24-q26 | 2(0/2/0) |
| PRKG1 | protein kinase, cGMP-dependent, type I | 10q11.2 | 1(0/0/1) |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | 2(1/0/1) |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 10(3/7/0) |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A | 13q14-q21 | 12(6/6/0) |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | Xq24 | 5(2/3/0) |
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) |
| DRD1 | dopamine receptor D1 | 5q34-q35 | 8(5/3/0) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| MAPK7 | mitogen-activated protein kinase 7 | 17p11.2 | Mapped by significant region |
| GJA1 | gap junction protein, alpha 1, 43kDa | 6q22-q23 | Mapped by significant region |
| TUBA4A | tubulin, alpha 4a | 2q36.1 | Mapped by significant region |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| LPAR1 | lysophosphatidic acid receptor 1 | 9q | Mapped by significant region |
| TUBB3 | tubulin, beta 3 | 16q24.3 | Mapped by significant region |
| TUBA3C | tubulin, alpha 3c | 13q12.11 | Mapped by significant region |
| TUBA3E | tubulin, alpha 3e | 2q21.1 | Mapped by significant region |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 | 11q21-q22 | Mapped by significant region |
| PDGFD | platelet derived growth factor D | 11q22.3 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| TJP1 | tight junction protein 1 (zona occludens 1) | 15q13 | Mapped by CNV; Mapped by significant region |
| TUBA3D | tubulin, alpha 3d | 2q21.1 | Mapped by CNV; Mapped by significant region |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |