ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

KEGG Pathway Report

Basic Info

ID	hsa05145
Name	Toxoplasmosis
Description	Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechanisms. During early infection, nuclear translocation of NFkB is temporally blocked and p38 MAPK phosphorylation is prevented, suppressing IL-12 production. Another pathway for IL-12 induction occurs through CCR5 dependent pathway, but parasitic induction of an eicosanoid LXA4 contributes to the downregulation of IL-12. Direct activation of STAT3 by the parasite enhance anti-inflammatory function of IL-10 and TGF beta. T. gondii can cause lifelong chronic infection by establishing an anti-apoptotic environment through induction of bcl-2 or IAPs and by redirecting LDL-mediated cholesterol transport to scavenge nutrients from the host.
No. of Genes in ADHDgene	33
Source	Pathway by Database Search

Pathway related genes in ADHDgene (count: 33)

Literature-origin genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	16q13	1(0/1/0)
HLA-DRB1	major histocompatibility complex, class II, DR beta 1	6p21.3	2(1/1/0)
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)

Genes from other sources (count: 30)

Approved Symbol	Approved Name	Location	Source
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	1p35	Mapped by PBA pathway
PLA2G1B	phospholipase A2, group IB (pancreas)	12q23-qter	Mapped by PBA pathway
PLA2G2E	phospholipase A2, group IIE	1p36.13	Mapped by PBA pathway
PLA2G2D	phospholipase A2, group IID	1p36.12	Mapped by PBA pathway
PLA2G4B	phospholipase A2, group IVB (cytosolic)	15q11.2-q21.3	Mapped by PBA pathway
PLA2G3	phospholipase A2, group III	22q12.2	Mapped by PBA pathway
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	5q31.1-q33.1	Mapped by significant region
PLA2G5	phospholipase A2, group V	1p36-p34	Mapped by PBA pathway
IL10RA	interleukin 10 receptor, alpha	11q23	Mapped by significant region
PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	22q13.1	Mapped by PBA pathway
CCR5	chemokine (C-C motif) receptor 5	3p21	Mapped by PBA pathway
MAPK1	mitogen-activated protein kinase 1	22q11.2	Mapped by LD-proxy
CYCS	cytochrome c, somatic	7p21.2	Mapped by CNV; Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	11q13	Mapped by significant region
HSPA8	heat shock 70kDa protein 8	11q24.1	Mapped by significant region
TLR4	toll-like receptor 4	9q33.1	Mapped by significant region
BAD	BCL2-associated agonist of cell death	11q13.1	Mapped by significant region
IFNGR1	interferon gamma receptor 1	6q23-q24	Mapped by significant region
MAPK9	mitogen-activated protein kinase 9	5q35	Mapped by CNV
MAPK3	mitogen-activated protein kinase 3	16p11.2	Mapped by CNV
BIRC2	baculoviral IAP repeat containing 2	11q22	Mapped by significant region
BIRC3	baculoviral IAP repeat containing 3	11q22	Mapped by significant region
LAMC2	laminin, gamma 2	1q25-q31	Mapped by significant region
PLA2G10	phospholipase A2, group X	16p13.1-p12	Mapped by PBA pathway; Mapped by significant region
LAMC1	laminin, gamma 1 (formerly LAMB2)	1q31	Mapped by significant region
LAMA3	laminin, alpha 3	18q11.2	Mapped by significant region
HSPA6	heat shock 70kDa protein 6 (HSP70B')	1q23.3	Mapped by CNV
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5q13.1	Mapped by significant region
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	7q22	Mapped by CNV
LAMA2	laminin, alpha 2	6q22-q23	Mapped by CNV; Mapped by significant region