ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0006805
Name	xenobiotic metabolic process
Type	Biological Process
No. of Genes in ADHDgene	25
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 25)

Literature-origin genes (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
COMT	catechol-O-methyltransferase	22q11.21	25(5/20/0)
MAOA	monoamine oxidase A	Xp11.4-p11.3	20(13/7/0)
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	2q37	1(0/0/1)	IDA[1910331]
MAOB	monoamine oxidase B	Xp11.4-p11.3	6(2/4/0)

Genes from other sources (count: 21)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ACSM2B	acyl-CoA synthetase medium-chain family member 2B	Mapped by significant region
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	Mapped by CNV
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mapped by CNV
PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	Mapped by significant region
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	Mapped by LD-proxy
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	Mapped by LD-proxy	IDA[3141926]
PAOX	polyamine oxidase (exo-N4-amino)	Mapped by CNV
AIP	aryl hydrocarbon receptor interacting protein	Mapped by significant region
UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	Mapped by LD-proxy
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	Mapped by significant region
UGT1A5	UDP glucuronosyltransferase 1 family, polypeptide A5	Mapped by LD-proxy
ACSM1	acyl-CoA synthetase medium-chain family member 1	Mapped by significant region
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	Mapped by significant region	IDA[8333863]
GGT1	gamma-glutamyltransferase 1	Mapped by CNV
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	Mapped by CNV
NNMT	nicotinamide N-methyltransferase	Mapped by significant region
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	Mapped by significant region	IDA[11300766]
GLYAT	glycine-N-acyltransferase	Mapped by LD-proxy; Mapped by significant region
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	Mapped by significant region	TAS[7835232]
UGT2B11	UDP glucuronosyltransferase 2 family, polypeptide B11	Mapped by significant region	TAS[8333863]
GSTP1	glutathione S-transferase pi 1	Mapped by significant region	IDA[1540159]