ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0006805
Name xenobiotic metabolic process
Type biological process
No. of Genes in ADHDgene  26
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 26)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2q37 1(0/0/1) IDA[1910331]
MAOA monoamine oxidase A Xp11.4-p11.3 20(13/7/0) TAS
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0) TAS
COMT catechol-O-methyltransferase 22q11.21 29(7/22/0) TAS

Genes from other sources Help (count: 22)

Approved Symbol Approved Name Source Evidence[PMID]
GSTP1 glutathione S-transferase pi 1 Mapped by significant region IDA[1540159]; TAS
ACSM1 acyl-CoA synthetase medium-chain family member 1 Mapped by significant region TAS
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV TAS
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 Mapped by significant region TAS[7835232]
GGT1 gamma-glutamyltransferase 1 Mapped by CNV TAS
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region TAS
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 Mapped by significant region TAS[8333863]
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mapped by CNV TAS
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 Mapped by significant region TAS
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 Mapped by significant region IDA[11300766]
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 Mapped by LD-proxy TAS
AIP aryl hydrocarbon receptor interacting protein Mapped by significant region IEA
GLYAT glycine-N-acyltransferase Mapped by LD-proxy; Mapped by significant region TAS
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 Mapped by LD-proxy IDA[3141926]; TAS
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 Mapped by CNV IDA; TAS
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy TAS
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Mapped by significant region TAS
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 Mapped by LD-proxy TAS
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 Mapped by LD-proxy NAS
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 Mapped by significant region IDA[8333863]
NNMT nicotinamide N-methyltransferase Mapped by significant region TAS
PAOX polyamine oxidase (exo-N4-amino) Mapped by CNV TAS