Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa00350 |
|---|---|
| Name | Tyrosine metabolism |
| No. of Genes in ADHDgene | 15 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 15)
Literature-origin genes (count: 7)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| TH | tyrosine hydroxylase | 11p15.5 | 7(2/5/0) |
| PNMT | phenylethanolamine N-methyltransferase | 17q | 3(2/1/0) |
| MAOB | monoamine oxidase B | Xp11.4-p11.3 | 6(2/4/0) |
| MAOA | monoamine oxidase A | Xp11.4-p11.3 | 20(13/7/0) |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 7p11 | 6(5/1/0) |
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | 9q34 | 20(11/9/0) |
| COMT | catechol-O-methyltransferase | 22q11.21 | 25(5/20/0) |
Genes from other sources (count: 8)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 17p11.2 | Mapped by significant region |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 6q11.1-q22.33 | Mapped by significant region |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 11q13 | Mapped by significant region |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 11q13 | Mapped by significant region |
| TYR | tyrosinase (oculocutaneous albinism IA) | 11q14-q21 | Mapped by significant region |
| LCMT2 | leucine carboxyl methyltransferase 2 | 15q15.3 | Mapped by LD-proxy |
| WBSCR22 | Williams Beuren syndrome chromosome region 22 | 7q11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| MIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 22q11.23 | Mapped by CNV |