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- Data Summary
GO Report
Basic Info
| ID | GO:0050796 |
|---|---|
| Name | regulation of insulin secretion |
| Type | Biological Process |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 22)
Literature-origin genes (count: 8)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| CNR1 | cannabinoid receptor 1 (brain) | 6q14-q15 | 1(1/0/0) | |
| SNAP25 | synaptosomal-associated protein, 25kDa | 20p12-p11.2 | 18(13/5/0) | |
| ADRA2A | adrenergic, alpha-2A-, receptor | 10q24-q26 | 12(4/8/0) | |
| STX1A | syntaxin 1A (brain) | 7q11.2 | 3(2/1/0) | |
| ADRA2C | adrenergic, alpha-2C-, receptor | 4p16.3 | 7(2/4/1) | |
| MTNR1B | melatonin receptor 1B | 11q21-q22 | 1(0/0/1) | |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 1(0/1/0) | |
| VAMP2 | vesicle-associated membrane protein 2 (synaptobrevin 2) | 17pter-p12 | 2(0/2/0) |
Genes from other sources (count: 14)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | Mapped by PBA pathway; Mapped by significant region | |
| SYT9 | synaptotagmin IX | Mapped by CNV | |
| RFX6 | regulatory factor X, 6 | Mapped by significant region | |
| CHRM3 | cholinergic receptor, muscarinic 3 | Mapped by CNV; Mapped by PBA pathway | |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | Mapped by significant region | |
| SYT7 | synaptotagmin VII | Mapped by significant region | |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | Mapped by LD-proxy; Mapped by literature SNP | |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | Mapped by CNV; Mapped by significant region | |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | Mapped by PBA pathway | |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | Mapped by PBA pathway | |
| SEC11C | SEC11 homolog C (S. cerevisiae) | Mapped by significant region | |
| INS | insulin | Mapped by literature SNP | |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | Mapped by CNV | |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | Mapped by CNV |