ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04270
Name Vascular smooth muscle contraction
Description  The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
No. of Genes in ADHDgene  33
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 33)

Literature-origin genes (count: 5)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
PRKG1 protein kinase, cGMP-dependent, type I 10q11.2 1(0/0/1)
ADRA1D adrenergic, alpha-1D-, receptor 20p13 1(0/1/0)
ADRA1A adrenergic, alpha-1A-, receptor 8p21.2 3(2/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
ADRA1B adrenergic, alpha-1B-, receptor 5q33.3 2(1/1/0)

Genes from other sources Help(count: 28)

Approved Symbol Approved Name Location Source
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1p35 Mapped by PBA pathway
PLA2G1B phospholipase A2, group IB (pancreas) 12q23-qter Mapped by PBA pathway
PLA2G2E phospholipase A2, group IIE 1p36.13 Mapped by PBA pathway
PLA2G2D phospholipase A2, group IID 1p36.12 Mapped by PBA pathway
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
PLA2G4B phospholipase A2, group IVB (cytosolic) 15q11.2-q21.3 Mapped by PBA pathway
PLA2G3 phospholipase A2, group III 22q12.2 Mapped by PBA pathway
PLA2G5 phospholipase A2, group V 1p36-p34 Mapped by PBA pathway
PLCB2 phospholipase C, beta 2 15q15 Mapped by PBA pathway
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 Mapped by PBA pathway
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by LD-proxy; Mapped by literature SNP
MYH11 myosin, heavy chain 11, smooth muscle 16p13.11 Mapped by CNV; Mapped by significant region
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Xp11.23 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 11q13 Mapped by significant region
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 11q21-q22 Mapped by significant region
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 Mapped by PBA pathway
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 Mapped by PBA pathway
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2p24 Mapped by significant region
ADORA2A adenosine A2a receptor 22q11.23 Mapped by CNV
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
PLA2G10 phospholipase A2, group X 16p13.1-p12 Mapped by PBA pathway; Mapped by significant region
PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B 1q32.1 Mapped by LD-proxy; Mapped by literature SNP
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 11q23.3 Mapped by significant region
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
EDNRA endothelin receptor type A 4 Mapped by PBA pathway
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014