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- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa03013 |
|---|---|
| Name | RNA transport |
| Description | RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. |
| No. of Genes in ADHDgene | 15 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 15)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| XPO1 | exportin 1 (CRM1 homolog, yeast) | 2p15 | 1(0/0/1) |
Genes from other sources (count: 14)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPP30 | ribonuclease P/MRP 30kDa subunit | 10q23.32-q23.33 | Mapped by LD-proxy |
| NUPL2 | nucleoporin like 2 | 7p15 | Mapped by CNV; Mapped by significant region |
| SAP18 | Sin3A-associated protein, 18kDa | 13q12.11 | Mapped by significant region |
| EIF2B1 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa | 12q24.3 | Mapped by CNV |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 11q13.5-q14 | Mapped by significant region |
| NCBP1 | nuclear cap binding protein subunit 1, 80kDa | 9q34.1 | Mapped by significant region |
| SIP1 | survival of motor neuron protein interacting protein 1 | 14q21.1 | Mapped by PBA pathway |
| NUP62 | nucleoporin 62kDa | 19 | Mapped by PBA pathway |
| NUP155 | nucleoporin 155kDa | 5p13.1 | Mapped by significant region |
| NXF1 | nuclear RNA export factor 1 | 11q12-q13 | Mapped by significant region |
| NMD3 | NMD3 homolog (S. cerevisiae) | 3q26.1 | Mapped by CNV |
| TRNT1 | tRNA nucleotidyl transferase, CCA-adding, 1 | 3p25.1 | Mapped by CNV |
| C9orf23 | chromosome 9 open reading frame 23 | 9p11.2 | Mapped by LD-proxy |
| RAN | RAN, member RAS oncogene family | 12 | Mapped by PBA pathway |