Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa04730 |
|---|---|
| Name | Long-term depression |
| Description | Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. |
| No. of Genes in ADHDgene | 27 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 27)
Literature-origin genes (count: 7)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GRID2 | glutamate receptor, ionotropic, delta 2 | 4q22 | 1(0/0/1) |
| PRKG1 | protein kinase, cGMP-dependent, type I | 10q11.2 | 1(0/0/1) |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 16q13 | 1(0/1/0) |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 22q11.1-q11.2 | 1(0/1/0) |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | 2(1/0/1) |
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) |
| NOS1 | nitric oxide synthase 1 (neuronal) | 12q14-qter | 1(1/0/0) |
Genes from other sources (count: 20)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 1p35 | Mapped by PBA pathway |
| PLA2G1B | phospholipase A2, group IB (pancreas) | 12q23-qter | Mapped by PBA pathway |
| PLA2G2E | phospholipase A2, group IIE | 1p36.13 | Mapped by PBA pathway |
| PLA2G2D | phospholipase A2, group IID | 1p36.12 | Mapped by PBA pathway |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 15q11.2-q21.3 | Mapped by PBA pathway |
| PLA2G3 | phospholipase A2, group III | 22q12.2 | Mapped by PBA pathway |
| PLA2G5 | phospholipase A2, group V | 1p36-p34 | Mapped by PBA pathway |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 22q13.1 | Mapped by PBA pathway |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 19p13 | Mapped by PBA pathway |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 | 11q21-q22 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| RYR1 | ryanodine receptor 1 (skeletal) | 19q13.1 | Mapped by PBA pathway |
| PLA2G10 | phospholipase A2, group X | 16p13.1-p12 | Mapped by PBA pathway; Mapped by significant region |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |