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KEGG Pathway Report
Basic Info
| ID | hsa04110 |
|---|---|
| Name | Cell cycle |
| Description | Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 18)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PLK1 | polo-like kinase 1 | 16p | Mapped by significant region |
| CDC26 | cell division cycle 26 homolog (S. cerevisiae) | 9q32 | Mapped by significant region |
| ANAPC4 | anaphase promoting complex subunit 4 | 4p15.31 | Mapped by CNV |
| E2F5 | E2F transcription factor 5, p130-binding | 8q21.2 | Mapped by CNV |
| CDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 9q22.3 | Mapped by significant region |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 2p25.2-p25.1 | Mapped by significant region |
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 11q24.2 | Mapped by significant region |
| SKP2 | S-phase kinase-associated protein 2 (p45) | 5p13 | Mapped by significant region |
| TTK | TTK protein kinase | 6q13-q21 | Mapped by PBA pathway |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| SMC1A | structural maintenance of chromosomes 1A | Xp11.22-p11.21 | Mapped by PBA pathway |
| ATM | ataxia telangiectasia mutated | 11q22-q23 | Mapped by CNV; Mapped by significant region |
| SMC3 | structural maintenance of chromosomes 3 | 10q25 | Mapped by PBA pathway |
| CDC25B | cell division cycle 25 homolog B (S. pombe) | 20p13 | Mapped by CNV |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 22q12.1-q13.1 | Mapped by PBA pathway |
| GADD45G | growth arrest and DNA-damage-inducible, gamma | 9q22.1-q22.2 | Mapped by significant region |
| CDC45 | cell division cycle 45 homolog (S. cerevisiae) | 22q11.21 | Mapped by CNV |
| PTTG1 | pituitary tumor-transforming 1 | 5q35.1 | Mapped by significant region |