ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0051056
Name	regulation of small GTPase mediated signal transduction
Type	Biological Process
No. of Genes in ADHDgene	30
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 30)

Literature-origin genes (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TIAM2	T-cell lymphoma invasion and metastasis 2	6q25	1(0/0/1)
NET1	neuroepithelial cell transforming 1	10p15	0
SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	12q13.13	1(0/0/1)
TRIO	triple functional domain (PTPRF interacting)	5p14-p15.1	1(0/0/1)

Genes from other sources (count: 26)

Approved Symbol	Approved Name	Source
ARHGAP11A	Rho GTPase activating protein 11A	Mapped by CNV; Mapped by significant region
ARHGAP8	Rho GTPase activating protein 8	Mapped by CNV
ARHGAP5	Rho GTPase activating protein 5	Mapped by significant region
RHOD	ras homolog gene family, member D	Mapped by significant region
GARNL3	GTPase activating Rap/RanGAP domain-like 3	Mapped by significant region
MCF2L	MCF.2 cell line derived transforming sequence-like	Mapped by CNV
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	Mapped by CNV
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
GAPVD1	GTPase activating protein and VPS9 domains 1	Mapped by significant region
FAM13A	family with sequence similarity 13, member A	Mapped by CNV
ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	Mapped by significant region
ARHGAP32	Rho GTPase activating protein 32	Mapped by significant region
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mapped by significant region
RASGEF1C	RasGEF domain family, member 1C	Mapped by CNV
FGD3	FYVE, RhoGEF and PH domain containing 3	Mapped by significant region
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	Mapped by significant region
ARHGAP19	Rho GTPase activating protein 19	Mapped by LD-proxy; Mapped by literature SNP
ARHGAP20	Rho GTPase activating protein 20	Mapped by significant region
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	Mapped by CNV
RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	Mapped by significant region
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	Mapped by significant region
ARHGAP11B	Rho GTPase activating protein 11B	Mapped by significant region
RGL1	ral guanine nucleotide dissociation stimulator-like 1	Mapped by significant region
CHN2	chimerin (chimaerin) 2	Mapped by CNV
ARHGAP18	Rho GTPase activating protein 18	Mapped by CNV; Mapped by significant region