ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0051056
Name regulation of small GTPase mediated signal transduction
Type biological process
No. of Genes in ADHDgene  32
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 32)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1) TAS
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) TAS
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS

Genes from other sources Help (count: 28)

Approved Symbol Approved Name Source Evidence[PMID]
GAPVD1 GTPase activating protein and VPS9 domains 1 Mapped by significant region IEA
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Mapped by significant region IEA
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway TAS
GARNL3 GTPase activating Rap/RanGAP domain-like 3 Mapped by significant region IEA
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV TAS
ARHGAP11B Rho GTPase activating protein 11B Mapped by CNV; Mapped by significant region TAS
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 Mapped by significant region IEA
ARHGAP32 Rho GTPase activating protein 32 Mapped by significant region TAS
ARHGAP8 Rho GTPase activating protein 8 Mapped by CNV TAS
ARHGAP5 Rho GTPase activating protein 5 Mapped by significant region TAS
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region TAS
RHOD ras homolog family member D Mapped by significant region TAS
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 Mapped by CNV TAS
CHN2 chimerin 2 Mapped by CNV TAS
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Mapped by significant region TAS
ARHGAP20 Rho GTPase activating protein 20 Mapped by significant region TAS
RGL1 ral guanine nucleotide dissociation stimulator-like 1 Mapped by significant region IEA
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region TAS
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region TAS
ARHGAP11A Rho GTPase activating protein 11A Mapped by CNV; Mapped by significant region TAS
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 Mapped by CNV IEA
ARHGAP18 Rho GTPase activating protein 18 Mapped by CNV; Mapped by significant region TAS
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma Mapped by significant region TAS
RASGEF1C RasGEF domain family, member 1C Mapped by CNV IEA
FAM13A family with sequence similarity 13, member A Mapped by CNV TAS
TSC2 tuberous sclerosis 2 Mapped by significant region IEA
RHOT2 ras homolog family member T2 Mapped by significant region TAS
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region TAS