ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004672
Name	protein kinase activity
Type	Molecular Function
No. of Genes in ADHDgene	27
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 27)

Literature-origin genes (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
ADRBK1	adrenergic, beta, receptor kinase 1	11q13	1(0/1/0)
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)	TAS[9747029]
ADRBK2	adrenergic, beta, receptor kinase 2	22q11	1(0/1/0)	TAS[8427589]
CSNK1E	casein kinase 1, epsilon	22q13.1	2(1/1/0)

Genes from other sources (count: 23)

Approved Symbol	Approved Name	Source	Evidence[PMID]
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region	IDA[17028174]
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	Mapped by CNV	IDA[9852112]
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region	IDA[9852149]
MLKL	mixed lineage kinase domain-like	Mapped by significant region
CCND1	cyclin D1	Mapped by significant region
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	Mapped by significant region
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Mapped by significant region	TAS[9804755]
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	TAS[8183572]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[19736306]
EEF2K	eukaryotic elongation factor-2 kinase	Mapped by CNV; Mapped by significant region	TAS[9144159]
FASTKD5	FAST kinase domains 5	Mapped by CNV
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Mapped by CNV	TAS[19376709]
PLK1	polo-like kinase 1	Mapped by significant region	IDA[17146433]
AURKC	aurora kinase C	Mapped by LD-proxy	IDA[15670791]
NRBP1	nuclear receptor binding protein 1	Mapped by PBA pathway
RIPK3	receptor-interacting serine-threonine kinase 3	Mapped by significant region	TAS[10358032]
SYK	spleen tyrosine kinase	Mapped by significant region	NAS[12885943]
CDK12	cyclin-dependent kinase 12	Mapped by LD-proxy	IDA[11683387]
PIK3C3	phosphoinositide-3-kinase, class 3	Mapped by significant region
POLR2G	polymerase (RNA) II (DNA directed) polypeptide G	Mapped by significant region	IDA[9852112]
SMG1	smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	Mapped by significant region	TAS[14636577]
CDKL2	cyclin-dependent kinase-like 2 (CDC2-related kinase)	Mapped by CNV	TAS[9000130]
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mapped by LD-proxy; Mapped by significant region