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- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa00380 |
|---|---|
| Name | Tryptophan metabolism |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 8)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| TPH1 | tryptophan hydroxylase 1 | 11p15.3-p14 | 6(2/4/0) |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 7p11 | 6(5/1/0) |
| AANAT | aralkylamine N-acetyltransferase | 17q25 | 1(0/0/1) |
| ASMT | acetylserotonin O-methyltransferase | Xp22.3 and Yp11.3 | 1(1/0/0) |
| TDO2 | tryptophan 2,3-dioxygenase | 4q31-q32 | 1(1/0/0) |
| MAOB | monoamine oxidase B | Xp11.4-p11.3 | 6(2/4/0) |
| MAOA | monoamine oxidase A | Xp11.4-p11.3 | 20(13/7/0) |
| TPH2 | tryptophan hydroxylase 2 | 12q15 | 10(7/3/0) |
Genes from other sources (count: 4)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 17p11.2 | Mapped by significant region |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | 10q26.2-q26.3 | Mapped by CNV |
| HAAO | 3-hydroxyanthranilate 3,4-dioxygenase | 2p | Mapped by LD-proxy |
| ACAT1 | acetyl-CoA acetyltransferase 1 | 11q22.3 | Mapped by CNV; Mapped by significant region |