Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa05222 |
|---|---|
| Name | Small cell lung cancer |
| Description | Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. |
| No. of Genes in ADHDgene | 16 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 16)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| FHIT | fragile histidine triad gene | 3p14.2 | 1(0/0/1) |
Genes from other sources (count: 15)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| BIRC2 | baculoviral IAP repeat containing 2 | 11q22 | Mapped by significant region |
| BIRC3 | baculoviral IAP repeat containing 3 | 11q22 | Mapped by significant region |
| FN1 | fibronectin 1 | 2q34 | Mapped by significant region |
| LAMC2 | laminin, gamma 2 | 1q25-q31 | Mapped by significant region |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 1q31 | Mapped by significant region |
| CYCS | cytochrome c, somatic | 7p21.2 | Mapped by CNV; Mapped by significant region |
| LAMA3 | laminin, alpha 3 | 18q11.2 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| SKP2 | S-phase kinase-associated protein 2 (p45) | 5p13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| TRAF1 | TNF receptor-associated factor 1 | 9q33-q34 | Mapped by significant region |
| LAMA2 | laminin, alpha 2 | 6q22-q23 | Mapped by CNV; Mapped by significant region |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 5q11.2 | Mapped by LD-proxy |