ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04910
Name Insulin signaling pathway
Description  Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
No. of Genes in ADHDgene  29
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 29)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 7q35-q36 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
HK1 hexokinase 1 10q22 1(0/1/0)
HKDC1 hexokinase domain containing 1 10q22.1 1(0/1/0)

Genes from other sources Help(count: 25)

Approved Symbol Approved Name Location Source
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 11q13.1 Mapped by significant region
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2 Mapped by significant region
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 5p12 Mapped by significant region
PHKG2 phosphorylase kinase, gamma 2 (testis) 16p11.2 Mapped by CNV
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 11q23.3-qter Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 9q22.1 Mapped by significant region
SREBF1 sterol regulatory element binding transcription factor 1 17p11.2 Mapped by significant region
BAD BCL2-associated agonist of cell death 11q13.1 Mapped by significant region
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 11q13 Mapped by significant region
LIPE lipase, hormone-sensitive 19q13.1-q13.2 Mapped by PBA pathway
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 22q11.21 Mapped by CNV
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 7q22.3 Mapped by CNV
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 1q21.2 Mapped by CNV
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
RPTOR regulatory associated protein of MTOR, complex 1 17q25.3 Mapped by LD-proxy
TSC1 tuberous sclerosis 1 9q34 Mapped by PBA pathway
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 Mapped by significant region
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22 Mapped by CNV
FBP2 fructose-1,6-bisphosphatase 2 9q22.3 Mapped by significant region
FBP1 fructose-1,6-bisphosphatase 1 9q22.3 Mapped by significant region
PYGM phosphorylase, glycogen, muscle 11q12-q13.2 Mapped by significant region
ACACA acetyl-CoA carboxylase alpha 17q21 Mapped by CNV
INS insulin 11p15.5 Mapped by literature SNP

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014