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- Data Summary
GO Report
Basic Info
| ID | GO:0043410 |
|---|---|
| Name | positive regulation of MAPK cascade |
| Type | Biological Process |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 17)
Literature-origin genes (count: 6)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| ADRA1B | adrenergic, alpha-1B-, receptor | 5q33.3 | 2(1/1/0) | |
| ADRB3 | adrenergic, beta-3-, receptor | 8p12 | 2(0/2/0) | IDA[15123695] |
| ADRB2 | adrenergic, beta-2-, receptor, surface | 5q31-q32 | 2(1/1/0) | IDA[15123695] |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 9q22.1 | 1(1/0/0) | |
| ADRA1A | adrenergic, alpha-1A-, receptor | 8p21.2 | 3(2/1/0) | |
| FGF10 | fibroblast growth factor 10 | 5p13-p12 | 1(0/1/0) | IDA[12804770] |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| TRIM5 | tripartite motif containing 5 | Mapped by CNV | |
| IL6 | interleukin 6 (interferon, beta 2) | Mapped by significant region | IDA[12419823] |
| IGF2 | insulin-like growth factor 2 (somatomedin A) | Mapped by LD-proxy; Mapped by literature SNP | IDA[11500939] |
| FGF9 | fibroblast growth factor 9 (glia-activating factor) | Mapped by significant region | |
| FLT4 | fms-related tyrosine kinase 4 | Mapped by CNV | IMP[19779139] |
| SORBS3 | sorbin and SH3 domain containing 3 | Mapped by PBA pathway | |
| LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Mapped by significant region | |
| CDON | Cdon homolog (mouse) | Mapped by significant region | |
| TBX1 | T-box 1 | Mapped by CNV | |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | Mapped by significant region | |
| INS | insulin | Mapped by literature SNP | IDA[11500939] |