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- Data Summary
GO Report
Basic Info
| ID | GO:0007188 |
|---|---|
| Name | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
| Type | Biological Process |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 13)
Literature-origin genes (count: 8)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| ADRB3 | adrenergic, beta-3-, receptor | 8p12 | 2(0/2/0) | TAS[1718744] |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 16q13 | 1(0/1/0) | |
| GNAT2 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 | 1p13 | 1(1/0/0) | |
| ADRA1B | adrenergic, alpha-1B-, receptor | 5q33.3 | 2(1/1/0) | TAS[10820200] |
| ADRA1D | adrenergic, alpha-1D-, receptor | 20p13 | 1(0/1/0) | TAS[10820200] |
| ADRB2 | adrenergic, beta-2-, receptor, surface | 5q31-q32 | 2(1/1/0) | TAS[2823249] |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 22q11.1-q11.2 | 1(0/1/0) | |
| CNR1 | cannabinoid receptor 1 (brain) | 6q14-q15 | 1(1/0/0) | IDA[18761332] |
Genes from other sources (count: 5)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | Mapped by PBA pathway | |
| ADORA2A | adenosine A2a receptor | Mapped by CNV | TAS[10899090] |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | Mapped by significant region | IDA[8163486] |
| MC4R | melanocortin 4 receptor | Mapped by significant region | TAS[8794897] |
| ADCY4 | adenylate cyclase 4 | Mapped by significant region |