ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

GO Report

Basic Info

ID	GO:0030036
Name	actin cytoskeleton organization
Type	Biological Process
No. of Genes in ADHDgene	21
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 21)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	TAS[9624180]
PRKG1	protein kinase, cGMP-dependent, type I	10q11.2	1(0/0/1)	TAS[10851246]

Genes from other sources (count: 19)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TAOK2	TAO kinase 2	Mapped by CNV	IDA[10660600]
CORO2A	coronin, actin binding protein, 2A	Mapped by significant region
ARFIP2	ADP-ribosylation factor interacting protein 2	Mapped by CNV	IMP[9312003]
CORO1B	coronin, actin binding protein, 1B	Mapped by significant region
TMSB4Y	thymosin beta 4, Y-linked	Mapped by PBA pathway
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region
ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	Mapped by significant region	IDA[12071859]
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	Mapped by significant region	TAS[9359840]
CORO1A	coronin, actin binding protein, 1A	Mapped by CNV	IMP[17442961]
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway	ISS[10729324]
CFL1	cofilin 1 (non-muscle)	Mapped by significant region	TAS[10436159]
NF2	neurofibromin 2 (merlin)	Mapped by PBA pathway	IMP[9537418]
FGD3	FYVE, RhoGEF and PH domain containing 3	Mapped by significant region
KLHL1	kelch-like 1 (Drosophila)	Mapped by CNV	NAS[10888605]
SPIRE2	spire homolog 2 (Drosophila)	Mapped by significant region
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	Mapped by PBA pathway; Mapped by significant region	IDA[10430899]
SPIRE1	spire homolog 1 (Drosophila)	Mapped by CNV
MON2	MON2 homolog (S. cerevisiae)	Mapped by PBA pathway
FMN1	formin 1	Mapped by CNV; Mapped by significant region