ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04912
Name GnRH signaling pathway
Description  Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
No. of Genes in ADHDgene  28
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 28)

Literature-origin genes (count: 2)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)

Genes from other sources Help(count: 26)

Approved Symbol Approved Name Location Source
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1p35 Mapped by PBA pathway
PLA2G1B phospholipase A2, group IB (pancreas) 12q23-qter Mapped by PBA pathway
PLA2G2E phospholipase A2, group IIE 1p36.13 Mapped by PBA pathway
PLA2G2D phospholipase A2, group IID 1p36.12 Mapped by PBA pathway
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
PLA2G4B phospholipase A2, group IVB (cytosolic) 15q11.2-q21.3 Mapped by PBA pathway
PLA2G3 phospholipase A2, group III 22q12.2 Mapped by PBA pathway
PLA2G5 phospholipase A2, group V 1p36-p34 Mapped by PBA pathway
CAMK2D calcium/calmodulin-dependent protein kinase II delta 4q26 Mapped by CNV
PLCB2 phospholipase C, beta 2 15q15 Mapped by PBA pathway
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 Mapped by PBA pathway
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
MAPK7 mitogen-activated protein kinase 7 17p11.2 Mapped by significant region
PLD1 phospholipase D1, phosphatidylcholine-specific 3q26 Mapped by PBA pathway
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by LD-proxy; Mapped by literature SNP
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Xp11.23 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 Mapped by PBA pathway
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 Mapped by PBA pathway
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
GNRHR gonadotropin-releasing hormone receptor 4q21.2 Mapped by significant region
PLA2G10 phospholipase A2, group X 16p13.1-p12 Mapped by PBA pathway; Mapped by significant region
PLD2 phospholipase D2 17p13.3 Mapped by PBA pathway
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014