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KEGG Pathway Report
Basic Info
| ID | hsa05100 |
|---|---|
| Name | Bacterial invasion of epithelial cells |
| Description | Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 2p12-p11.1 | 2(1/1/0) |
| DNM1 | dynamin 1 | 9q34 | 1(0/0/1) |
Genes from other sources (count: 17)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CAV3 | caveolin 3 | 3p25 | Mapped by LD-proxy; Mapped by literature SNP |
| WASL | Wiskott-Aldrich syndrome-like | 7q31.3 | Mapped by CNV |
| FN1 | fibronectin 1 | 2q34 | Mapped by significant region |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11q23.3-qter | Mapped by significant region |
| CLTCL1 | clathrin, heavy chain-like 1 | 22q11.2 | Mapped by CNV |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 9q22.1 | Mapped by significant region |
| ARPC5L | actin related protein 2/3 complex, subunit 5-like | 9q34.11 | Mapped by significant region |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 1q | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 2q36.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 10q21 | Mapped by CNV |
| ILK | integrin-linked kinase | 11p15.4 | Mapped by CNV |
| SEPT1 | septin 1 | 16p11.1 | Mapped by CNV |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 16q22-q23 | Mapped by significant region |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| CTTN | cortactin | 11q13 | Mapped by significant region |