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KEGG Pathway Report
Basic Info
| ID | hsa04310 |
|---|---|
| Name | Wnt signaling pathway |
| Description | Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 22)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CSNK1E | casein kinase 1, epsilon | 22q13.1 | 2(1/1/0) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
| MMP7 | matrix metallopeptidase 7 (matrilysin, uterine) | 11q21-q22 | 1(0/0/1) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| WNT11 | wingless-type MMTV integration site family, member 11 | 11q13.5 | Mapped by significant region |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 14q11.2 | Mapped by significant region |
| WNT10A | wingless-type MMTV integration site family, member 10A | 2q35 | Mapped by significant region |
| WNT6 | wingless-type MMTV integration site family, member 6 | 2q35 | Mapped by significant region |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 4q26 | Mapped by CNV |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| APC | adenomatous polyposis coli | 5q21-q22 | Mapped by LD-proxy; Mapped by PBA pathway |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | 11q12 | Mapped by significant region |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| FZD4 | frizzled family receptor 4 | 11q14-q21 | Mapped by significant region |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta | 9q31 | Mapped by significant region |
| CACYBP | calcyclin binding protein | 1q24-q25 | Mapped by significant region |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| LRP5 | low density lipoprotein receptor-related protein 5 | 11q13.4 | Mapped by CNV; Mapped by significant region |
| FOSL1 | FOS-like antigen 1 | 11q13 | Mapped by significant region |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 2p24 | Mapped by significant region |