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KEGG Pathway Report
Basic Info
| ID | hsa05322 |
|---|---|
| Name | Systemic lupus erythematosus |
| Description | Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 4)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| H2AFY | H2A histone family, member Y | 5q31.1 | 1(0/1/0) |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16p13.2 | 3(1/2/0) |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 12p12 | 1(1/0/0) |
Genes from other sources (count: 15)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| C9 | complement component 9 | 5p14-p12 | Mapped by significant region |
| ACTN3 | actinin, alpha 3 | 11q13-q14 | Mapped by significant region |
| C7 | complement component 7 | 5 | Mapped by significant region |
| SNRPD3 | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 22q11.23 | Mapped by CNV; Mapped by PBA pathway |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 18q11.2 | Mapped by significant region |
| C6 | complement component 6 | 5 | Mapped by significant region |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 1q23 | Mapped by CNV |
| FCGR3A | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 1q23 | Mapped by CNV |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 1q23 | Mapped by CNV |
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | 1q23 | Mapped by CNV |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 1q23 | Mapped by CNV |
| H2AFX | H2A histone family, member X | 11q23.3 | Mapped by significant region |
| CTSG | cathepsin G | 14q12 | Mapped by significant region |
| C5 | complement component 5 | 9q33-q34 | Mapped by significant region |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 20p13 | Mapped by PBA pathway |