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KEGG Pathway Report
Basic Info
| ID | hsa03008 |
|---|---|
| Name | Ribosome biogenesis in eukaryotes |
| Description | Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| XPO1 | exportin 1 (CRM1 homolog, yeast) | 2p15 | 1(0/0/1) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| DROSHA | drosha, ribonuclease type III | 5q11.2 | Mapped by significant region |
| RPP30 | ribonuclease P/MRP 30kDa subunit | 10q23.32-q23.33 | Mapped by LD-proxy |
| IMP4 | IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) | 2q21.1 | Mapped by significant region |
| REXO1L1 | REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 | 8q21.2 | Mapped by CNV |
| NXF1 | nuclear RNA export factor 1 | 11q12-q13 | Mapped by significant region |
| NMD3 | NMD3 homolog (S. cerevisiae) | 3q26.1 | Mapped by CNV |
| REXO2 | REX2, RNA exonuclease 2 homolog (S. cerevisiae) | 11q23.2 | Mapped by significant region |
| C9orf23 | chromosome 9 open reading frame 23 | 9p11.2 | Mapped by LD-proxy |
| RAN | RAN, member RAS oncogene family | 12 | Mapped by PBA pathway |
| NOP10 | NOP10 ribonucleoprotein homolog (yeast) | 15q14-q15 | Mapped by CNV |
| EIF6 | eukaryotic translation initiation factor 6 | 20q11.2 | Mapped by LD-proxy |