ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NOP10
Previous Symbol	NOLA3
Symbol Alias	NOP10P, MGC70651
Approved Name	NOP10 ribonucleoprotein homolog (yeast)
Previous Name	nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
Name Alias	homolog of yeast Nop10p
Location	15q14-q15
Position	chr15:34633914-34635378, -
External Links	HGNC: 14378 Entrez Gene: 55505 Ensembl: ENSG00000182117 UCSC: uc001zie.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_44	chr15:30688712-32587887 (NCBI Build 36.1 (hg18))	1871368	15q13.3-15q14	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005732	small nucleolar ribonucleoprotein complex	Cellular Component	TAS[9843512]	1
GO:0005730	nucleolus	Cellular Component		243
GO:0005515	protein binding	Molecular Function	IPI[16601202]	910
GO:0001522	pseudouridine synthesis	Biological Process	NAS[9843512]	3
GO:0015030	Cajal body	Cellular Component		11
GO:0006364	rRNA processing	Biological Process		5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...

Genes shared at least 5 GO terms with NOP10 (count: 0)

Genes shared at least 2 KEGG pathways with NOP10 (count: 0)

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Region: chr15:34633914..34635378 View in gBrowse