ADHDgene Database

Gene Report

Basic Info

Approved Symbol	EIF6
Previous Symbol	EIF3A, ITGB4BP
Symbol Alias	p27BBP, b(2)gcn
Approved Name	eukaryotic translation initiation factor 6
Previous Name	integrin beta 4 binding protein
Location	20q11.2
Position	chr20:33866714-33872788, -
External Links	HGNC: 6159 Entrez Gene: 3692 Ensembl: ENSG00000242372 UCSC: uc002xbv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation
rs2425048	Chr20:33872723(Fwd)	5_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs2425046	Chr20:33871661(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	770
GO:0005638	lamin filament	Cellular Component	1
GO:0005730	nucleolus	Cellular Component	243
GO:0005737	cytoplasm	Cellular Component	690
GO:0042256	mature ribosome assembly	Biological Process	1
GO:0042273	ribosomal large subunit biogenesis	Biological Process	2
GO:0043022	ribosome binding	Molecular Function	4
GO:0043023	ribosomal large subunit binding	Molecular Function	1
GO:0000054	ribosomal subunit export from nucleus	Biological Process	1
GO:0005515	protein binding	Molecular Function	910
GO:0003743	translation initiation factor activity	Molecular Function	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...

Genes shared at least 5 GO terms with EIF6 (count: 0)

Genes shared at least 2 KEGG pathways with EIF6 (count: 0)

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Region: chr20:33866714..33872788 View in gBrowse