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KEGG Pathway Report
Basic Info
| ID | hsa04622 |
|---|---|
| Name | RIG-I-like receptor signaling pathway |
| Description | Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. |
| No. of Genes in ADHDgene | 10 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 10)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| MAVS | mitochondrial antiviral signaling protein | 20p13 | Mapped by CNV |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| ATG5 | ATG5 autophagy related 5 homolog (S. cerevisiae) | 6q21 | Mapped by CNV |
| NLRX1 | NLR family member X1 | 11q23.3 | Mapped by significant region |
| FADD | Fas (TNFRSF6)-associated via death domain | 11q13.3 | Mapped by significant region |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| DAK | dihydroxyacetone kinase 2 homolog (S. cerevisiae) | 11q12.2 | Mapped by significant region |
| RNF125 | ring finger protein 125 | 18q12.1 | Mapped by significant region |
| IRF7 | interferon regulatory factor 7 | 11p15.5 | Mapped by LD-proxy |