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KEGG Pathway Report
Basic Info
| ID | hsa04720 |
|---|---|
| Name | Long-term potentiation |
| Description | Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP). |
| No. of Genes in ADHDgene | 15 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 15)
Literature-origin genes (count: 5)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | 2(1/0/1) |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16p13.2 | 3(1/2/0) |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 12p12 | 1(1/0/0) |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 1(0/1/0) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 4q26 | Mapped by CNV |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 11q13 | Mapped by significant region |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta | 9q31 | Mapped by significant region |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |