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KEGG Pathway Report
Basic Info
| ID | hsa04512 |
|---|---|
| Name | ECM-receptor interaction |
| Description | The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ITGA11 | integrin, alpha 11 | 15q22.3-q23 | 1(0/0/1) |
| ITGA1 | integrin, alpha 1 | 5q11.1 | 1(0/1/0) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| TNR | tenascin R (restrictin, janusin) | 1q24 | Mapped by significant region |
| SV2C | synaptic vesicle glycoprotein 2C | 5q13 | Mapped by CNV |
| FN1 | fibronectin 1 | 2q34 | Mapped by significant region |
| LAMC2 | laminin, gamma 2 | 1q25-q31 | Mapped by significant region |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 1q31 | Mapped by significant region |
| TNN | tenascin N | 1q23-q24 | Mapped by significant region |
| LAMA3 | laminin, alpha 3 | 18q11.2 | Mapped by significant region |
| GP1BB | glycoprotein Ib (platelet), beta polypeptide | 22q11.21-q11.23 | Mapped by CNV |
| TNC | tenascin C | 9q32-q34 | Mapped by significant region |
| LAMA2 | laminin, alpha 2 | 6q22-q23 | Mapped by CNV; Mapped by significant region |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 5q11.2 | Mapped by LD-proxy |