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KEGG Pathway Report
Basic Info
| ID | hsa04520 |
|---|---|
| Name | Adherens junction |
| Description | Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion. |
| No. of Genes in ADHDgene | 14 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 14)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 2p12-p11.1 | 2(1/1/0) |
| BAIAP2 | BAI1-associated protein 2 | 17q25 | 1(1/0/0) |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 11p11.2 | 1(0/1/0) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| YES1 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 18p11.31-p11.21 | Mapped by CNV |
| TGFBR1 | transforming growth factor, beta receptor 1 | 9q22 | Mapped by significant region |
| ACTN3 | actinin, alpha 3 | 11q13-q14 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| WASL | Wiskott-Aldrich syndrome-like | 7q31.3 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 11q12.1 | Mapped by significant region |
| TJP1 | tight junction protein 1 (zona occludens 1) | 15q13 | Mapped by CNV; Mapped by significant region |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 10q21 | Mapped by CNV |
| PVRL1 | poliovirus receptor-related 1 (herpesvirus entry mediator C) | 11q23-q24 | Mapped by significant region |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 17q11.2-q12 | Mapped by LD-proxy |