ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007169
Name transmembrane receptor protein tyrosine kinase signaling pathway
Type biological process
No. of Genes in ADHDgene  16
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 16)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0) TAS
NTF3 neurotrophin 3 12p13 4(1/3/0) IDA
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) TAS
PTPRG protein tyrosine phosphatase, receptor type, G 3p21-p14 1(0/0/1) TAS[8382771]

Genes from other sources Help (count: 12)

Approved Symbol Approved Name Source Evidence[PMID]
ROS1 c-ros oncogene 1 , receptor tyrosine kinase Mapped by significant region IEA
AHI1 Abelson helper integration site 1 Mapped by significant region ISS
GAB2 GRB2-associated binding protein 2 Mapped by significant region IDA[19172738]
STAP1 signal transducing adaptor family member 1 Mapped by significant region IEA
FLT4 fms-related tyrosine kinase 4 Mapped by CNV TAS[10835628]
ROR2 receptor tyrosine kinase-like orphan receptor 2 Mapped by significant region IEA
MUSK muscle, skeletal, receptor tyrosine kinase Mapped by significant region TAS[7546737]
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 Mapped by significant region TAS[8808684]
CD3E CD3e molecule, epsilon (CD3-TCR complex) Mapped by significant region TAS[8530500]
BDKRB2 bradykinin receptor B2 Mapped by PBA pathway TAS[10653985]
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 Mapped by LD-proxy IDA[7514177]; TAS[7556068]
ADORA2A adenosine A2a receptor Mapped by CNV TAS