ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0051493
Name	regulation of cytoskeleton organization
Type	Biological Process
No. of Genes in ADHDgene	32
Source	Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)

Data Set Reference	Gene Set	Mapping Rule	P-value	FDR	Result Link
Lesch KP, 2008	MsigDB 3.0 c5.bp	500kb upstream and downstream of gene	< 0.001	0.04	Link

GO related genes in ADHDgene (count: 32)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
CLASP2	cytoplasmic linker associated protein 2	3p24.3	1(0/0/1)

Genes from other sources (count: 31)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	Mapped by PBA pathway
MAPT	microtubule-associated protein tau	Mapped by LD-proxy; Mapped by PBA pathway
NEXN	nexilin (F actin binding protein)	Mapped by PBA pathway	IEP[15823560]
GSN	gelsolin	Mapped by PBA pathway; Mapped by significant region
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	Mapped by PBA pathway
LIMA1	LIM domain and actin binding 1	Mapped by PBA pathway
SORBS3	sorbin and SH3 domain containing 3	Mapped by PBA pathway
KATNB1	katanin p80 (WD repeat containing) subunit B 1	Mapped by PBA pathway
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	Mapped by PBA pathway; Mapped by significant region
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway
MAPRE1	microtubule-associated protein, RP/EB family, member 1	Mapped by PBA pathway
CLASP1	cytoplasmic linker associated protein 1	Mapped by PBA pathway
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
NCK1	NCK adaptor protein 1	Mapped by PBA pathway
NEBL	nebulette	Mapped by PBA pathway
CRIPAK	cysteine-rich PAK1 inhibitor	Mapped by PBA pathway	IDA[16278681]
MARK2	MAP/microtubule affinity-regulating kinase 2	Mapped by significant region
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway
NCK2	NCK adaptor protein 2	Mapped by PBA pathway
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV	TAS[19565474]
TSC1	tuberous sclerosis 1	Mapped by PBA pathway
RASA1	RAS p21 protein activator (GTPase activating protein) 1	Mapped by PBA pathway
CDC42EP5	CDC42 effector protein (Rho GTPase binding) 5	Mapped by PBA pathway
CAPG	capping protein (actin filament), gelsolin-like	Mapped by PBA pathway
CCDC88A	coiled-coil domain containing 88A	Mapped by PBA pathway
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	Mapped by PBA pathway
ARF6	ADP-ribosylation factor 6	Mapped by PBA pathway
TMSB4Y	thymosin beta 4, Y-linked	Mapped by PBA pathway
NF2	neurofibromin 2 (merlin)	Mapped by PBA pathway
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy	TAS[19565474]
CEP250	centrosomal protein 250kDa	Mapped by PBA pathway