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- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa05160 |
|---|---|
| Name | Hepatitis C |
| Description | Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 17)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 4p16.1 | 1(1/0/0) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 15)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAVS | mitochondrial antiviral signaling protein | 20p13 | Mapped by CNV |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CLDN5 | claudin 5 | 22q11.21 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| SCARB1 | scavenger receptor class B, member 1 | 12q24.32 | Mapped by CNV |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| IRF7 | interferon regulatory factor 7 | 11p15.5 | Mapped by LD-proxy |
| IRF9 | interferon regulatory factor 9 | 14q11.2 | Mapped by significant region |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | 1q25 | Mapped by significant region |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 10q26.3 | Mapped by CNV |