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KEGG Pathway Report
Basic Info
| ID | hsa05146 |
|---|---|
| Name | Amoebiasis |
| Description | Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | 18p11.22-p11.21 | 1(1/0/0) |
Genes from other sources (count: 18)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| C9 | complement component 9 | 5p14-p12 | Mapped by significant region |
| ACTN3 | actinin, alpha 3 | 11q13-q14 | Mapped by significant region |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| FN1 | fibronectin 1 | 2q34 | Mapped by significant region |
| LAMC2 | laminin, gamma 2 | 1q25-q31 | Mapped by significant region |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 1q31 | Mapped by significant region |
| LAMA3 | laminin, alpha 3 | 18q11.2 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| CTSG | cathepsin G | 14q12 | Mapped by significant region |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| LAMA2 | laminin, alpha 2 | 6q22-q23 | Mapped by CNV; Mapped by significant region |
| ARG1 | arginase, liver | 6q23 | Mapped by significant region |