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KEGG Pathway Report
Basic Info
| ID | hsa04670 |
|---|---|
| Name | Leukocyte transendothelial migration |
| Description | Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 22)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 2p12-p11.1 | 2(1/1/0) |
Genes from other sources (count: 21)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 16p13.1-p11 | Mapped by CNV |
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| ACTN3 | actinin, alpha 3 | 11q13-q14 | Mapped by significant region |
| CYBA | cytochrome b-245, alpha polypeptide | 16q24 | Mapped by significant region |
| ESAM | endothelial cell adhesion molecule | 11q24.2 | Mapped by significant region |
| CLDN5 | claudin 5 | 22q11.21 | Mapped by CNV |
| NCF2 | neutrophil cytosolic factor 2 | 1q25 | Mapped by significant region |
| THY1 | Thy-1 cell surface antigen | 11q23.3 | Mapped by significant region |
| JAM3 | junctional adhesion molecule 3 | 11q25 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| ITK | IL2-inducible T-cell kinase | 5q31-q32 | Mapped by significant region |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | 16p11.2 | Mapped by CNV |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 11q12.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| SIPA1 | signal-induced proliferation-associated 1 | 11q13.3 | Mapped by significant region |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 10q21 | Mapped by CNV |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 10q11.1 | Mapped by PBA pathway |
| ARHGAP5 | Rho GTPase activating protein 5 | 14q12 | Mapped by significant region |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 16q22-q23 | Mapped by significant region |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 16q24.1 | Mapped by significant region |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 2p24 | Mapped by significant region |