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KEGG Pathway Report
Basic Info
| ID | hsa03018 |
|---|---|
| Name | RNA degradation |
| Description | The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 8)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CNOT6 | CCR4-NOT transcription complex, subunit 6 | 5q35.3 | Mapped by CNV |
| RQCD1 | RCD1 required for cell differentiation1 homolog (S. pombe) | 2q35 | Mapped by significant region |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 11q23.3 | Mapped by significant region |
| BTG4 | B-cell translocation gene 4 | 11q23 | Mapped by significant region |
| PATL1 | protein associated with topoisomerase II homolog 1 (yeast) | 11q12.1 | Mapped by significant region |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 19p13.1 | Mapped by PBA pathway |
| MPHOSPH6 | M-phase phosphoprotein 6 | 16q23.3 | Mapped by significant region |
| DCPS | decapping enzyme, scavenger | 11q24 | Mapped by significant region |