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KEGG Pathway Report
Basic Info
| ID | hsa04930 |
|---|---|
| Name | Type II diabetes mellitus |
| Description | Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process. |
| No. of Genes in ADHDgene | 14 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 14)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HK1 | hexokinase 1 | 10q22 | 1(0/1/0) |
| HKDC1 | hexokinase domain containing 1 | 10q22.1 | 1(0/1/0) |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 1(0/1/0) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 1q25-q31 | Mapped by PBA pathway; Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CACNA1B | calcium channel, voltage-dependent, N type, alpha 1B subunit | 9q34 | Mapped by PBA pathway |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 19p13 | Mapped by PBA pathway |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| CACNA1G | calcium channel, voltage-dependent, T type, alpha 1G subunit | 17q22 | Mapped by PBA pathway |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3p14.3 | Mapped by PBA pathway |
| INS | insulin | 11p15.5 | Mapped by literature SNP |