ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04141
Name Protein processing in endoplasmic reticulum
Description  The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
No. of Genes in ADHDgene  26
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 26)

Literature-origin genes (count: 1)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 6q25.2-q27 1(1/0/0)

Genes from other sources Help(count: 25)

Approved Symbol Approved Name Location Source
GANAB glucosidase, alpha; neutral AB 11q12.3 Mapped by significant region
DERL3 Der1-like domain family, member 3 22q11.23 Mapped by CNV
MAN1A1 mannosidase, alpha, class 1A, member 1 6q22 Mapped by significant region
MAP3K5 mitogen-activated protein kinase kinase kinase 5 6q22.33 Mapped by LD-proxy; Mapped by significant region
CRYAB crystallin, alpha B 11q22.3-q23.1 Mapped by significant region
CANX calnexin 5q35 Mapped by CNV
RAD23B RAD23 homolog B (S. cerevisiae) 9q31.2 Mapped by significant region
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 1q25 Mapped by significant region
ATF6 activating transcription factor 6 1q22-q23 Mapped by CNV
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 9q33.3 Mapped by significant region
HSPA8 heat shock 70kDa protein 8 11q24.1 Mapped by significant region
LMAN1 lectin, mannose-binding, 1 18q21.3-q22 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by significant region
UFD1L ubiquitin fusion degradation 1 like (yeast) 22q11.2 Mapped by CNV
HYOU1 hypoxia up-regulated 1 11q23.1-q23.3 Mapped by significant region
SYVN1 synovial apoptosis inhibitor 1, synoviolin 11q13 Mapped by significant region
PDIA6 protein disulfide isomerase family A, member 6 2p25.1 Mapped by significant region
PDIA3 protein disulfide isomerase family A, member 3 15q15 Mapped by PBA pathway
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 20q11.22 Mapped by LD-proxy; Mapped by literature SNP
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 11q23.3 Mapped by significant region
HSPA6 heat shock 70kDa protein 6 (HSP70B') 1q23.3 Mapped by CNV
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2q32-q34 Mapped by significant region
MBTPS1 membrane-bound transcription factor peptidase, site 1 16q24 Mapped by CNV; Mapped by significant region
CAPN1 calpain 1, (mu/I) large subunit 11q13 Mapped by significant region
SEC61B Sec61 beta subunit 9q22.32-q31.3 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014