ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04380
Name Osteoclast differentiation
Description  The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
No. of Genes in ADHDgene  25
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 25)

Literature-origin genes (count: 0)

Genes from other sources Help(count: 25)

Approved Symbol Approved Name Location Source
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 11q13 Mapped by significant region
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 19q13.4 Mapped by CNV
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 19q13.4 Mapped by CNV
SQSTM1 sequestosome 1 5q35 Mapped by CNV
SYK spleen tyrosine kinase 9q22 Mapped by significant region
FOSL1 FOS-like antigen 1 11q13 Mapped by significant region
IFNGR1 interferon gamma receptor 1 6q23-q24 Mapped by significant region
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
TGFBR1 transforming growth factor, beta receptor 1 9q22 Mapped by significant region
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 18q22.1 Mapped by CNV
CYBA cytochrome b-245, alpha polypeptide 16q24 Mapped by significant region
NCF2 neutrophil cytosolic factor 2 1q25 Mapped by significant region
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1q23 Mapped by CNV
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1q23 Mapped by CNV
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 Mapped by significant region
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1q23 Mapped by CNV
GAB2 GRB2-associated binding protein 2 11q13.4-q13.5 Mapped by significant region
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22 Mapped by CNV
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 1q23 Mapped by CNV
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1q23 Mapped by CNV
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 11p12-p11.22 Mapped by LD-proxy
IRF9 interferon regulatory factor 9 14q11.2 Mapped by significant region
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014