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KEGG Pathway Report
Basic Info
| ID | hsa00510 |
|---|---|
| Name | N-Glycan biosynthesis |
| Description | N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. |
| No. of Genes in ADHDgene | 11 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 11)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| MAN2A2 | mannosidase, alpha, class 2A, member 2 | 15q25 | 1(0/0/1) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| GANAB | glucosidase, alpha; neutral AB | 11q12.3 | Mapped by significant region |
| ALG9 | asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) | 11q23 | Mapped by significant region |
| ALG2 | asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) | 9q31.1 | Mapped by significant region |
| ALG8 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) | 11pter-p15.5 | Mapped by significant region |
| STT3A | STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) | 11q23.3 | Mapped by significant region |
| ALG10 | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe) | 12p11.21 | Mapped by CNV |
| MGAT1 | mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | 5 | Mapped by CNV |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 6q22 | Mapped by significant region |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 5q35 | Mapped by CNV |
| DPAGT1 | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) | 11q23.3 | Mapped by significant region |