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KEGG Pathway Report
Basic Info
| ID | hsa04514 |
|---|---|
| Name | Cell adhesion molecules (CAMs) |
| Description | Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. |
| No. of Genes in ADHDgene | 20 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 20)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
| NEGR1 | neuronal growth regulator 1 | 1p31.1 | 1(1/0/0) |
| NRXN1 | neurexin 1 | 2p16.3 | 1(0/1/0) |
Genes from other sources (count: 17)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 16p13.1-p11 | Mapped by CNV |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 18q12.1 | Mapped by significant region |
| CNTNAP2 | contactin associated protein-like 2 | 7q35 | Mapped by CNV |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 16q24.3 | Mapped by CNV; Mapped by significant region |
| NLGN1 | neuroligin 1 | 3q26.32 | Mapped by CNV |
| NCAM1 | neural cell adhesion molecule 1 | 11q23-q24 | Mapped by significant region |
| ESAM | endothelial cell adhesion molecule | 11q24.2 | Mapped by significant region |
| CLDN5 | claudin 5 | 22q11.21 | Mapped by CNV |
| CD6 | CD6 molecule | 11q12.2 | Mapped by significant region |
| NRXN2 | neurexin 2 | 11q13 | Mapped by significant region |
| JAM3 | junctional adhesion molecule 3 | 11q25 | Mapped by significant region |
| SPN | sialophorin | 16p11.2 | Mapped by CNV |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 20p13 | Mapped by CNV |
| GLG1 | golgi glycoprotein 1 | 16q22-q23 | Mapped by significant region |
| PVRL1 | poliovirus receptor-related 1 (herpesvirus entry mediator C) | 11q23-q24 | Mapped by significant region |
| CADM1 | cell adhesion molecule 1 | 11q23.2 | Mapped by significant region |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 20q13.3 | Mapped by CNV |