ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NEGR1
Symbol Alias	KILON, MGC46680, Ntra, IGLON4
Approved Name	neuronal growth regulator 1
Name Alias	a kindred of IgLON, "neurotractin", "IgLON family member 4"
Location	1p31.1
Position	chr1:71868625-72748417, -
External Links	HGNC: 17302 Entrez Gene: 257194 Ensembl: ENSG00000172260 UCSC: uc001dfw.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_5	chr1:72317292-72328395 (NCBI36 / hg18)	11104	1p31.1	Dup	0:3:0(100%)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 4)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	910
GO:0005886	plasma membrane	Cellular Component	772
GO:0007155	cell adhesion	Biological Process	86
GO:0031225	anchored to membrane	Cellular Component	29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with NEGR1 (count: 0)

Genes shared at least 2 KEGG pathways with NEGR1 (count: 0)

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Region: chr1:71868625..72748417 View in gBrowse